• How is the success of the infusion measured? Uterine tone grading? Is there opportunity to
standardize oxytocin infusion rates across sites?
o Wandana Joshi, Darmouth: We don’t do anything formal but get feedback from the
surgeon while closing the uterus and sometimes need to initiate that discussion. In
terms of standardizing oxytocin infusion rates I think this would be really challenging.
o Monica Servin (MPOG OB Chair) - At U of M we have tried to standardize but were not
successful. We often find that we tend to ask the questions first to the obstetrician.
o Christine Warrick (University of Utah) – our experience is similar; either tone is good or
tone is not good and we adjust our rate based on that answer
▪ We use the standardized infusion described by ______ 300milliunits/hr then
escalate to secondary uterine tone agents if needed
o Mike Mathis (MPOG Research Director) – has this group looked at these second line
agents and how often its happening and whether there is a need for rescue agents?
▪ Monica Servin (MPOG OB Chair) - Not that I’m aware of
▪ Mike Mathis (MPOG Research Director) – without a structured process for
rating uterine tone, is that even getting into the medical record? What is
documented is the medication administered. Similar to PONV measures looking
at antiemetics given in PACU, but considering an outcome measure looking at
the escalation of uterine tonics
▪ Wandana Joshi, Darmouth – we base our oxytocin infusion based on
postpartum hemorrhage risk. So someone who is at risk we have a low, medium
and high. If we give a low dose it’s a lower bolus (1mL) to high bolus (3mL). It
would be interesting to see which patients are high risk and if they are receiving
these additional agents
▪ Monica Servin (MPOG OB Chair) – infusion is guided for us based on scheduled
vs. conversion c-section. We have a pretty high postpartum hemmorhage rate
so I agree it would make sense to look at this data and see where we could
improve
▪ Mike Mathis (MPOG Research Director) – It sounds like most sites have a site
specific ‘standard’ protocol but maybe the first escalation isn’t an escalation
drug but a dose above the standard oxytocin. Ie define escalated uterine tonics
per site.
• Has anyone experienced adverse effects from oxytocin infusion in their patients?
o Monica Servin (MPOG OB Chair) – very uncommon or atleast mild hypotension which is
manageable but I haven’t seen anything major
o Christine Warrick (University of Utah) – I agree. There seems to be more hypotension
but its time for that to be happening and there is sometimes increased nausea after we
start oxytocin at a higher dose
o Brandon Togioka (OHSU) - I have seen chest tightness with higher doses and if you slow
it down it goes away
▪ Monica Servin (MPOG OB Chair) - I have also heard that but hard to determine
if that’s from oxytocin or uterus externalization
▪ Brandon Togioka (OHSU) – we are trying to transition away from externalizing
but most OB/GYNs are still doing it
▪ Wandana Joshi (Darmouth) – we have recently gotten our OB/GYNs together to
have a more family centered approach and we decided to have the partner